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정가정보Phosphoribokinase
47 년 ago

Phosphoribokinase

phosphoribokinase

Identifiers

EC number
2.7.1.18

CAS number
9030-59-5

Databases

IntEnz
IntEnz view

BRENDA
BRENDA entry

ExPASy
NiceZyme view

KEGG
KEGG entry

MetaCyc
metabolic pathway

PRIAM
profile

PDB structures
RCSB PDB PDBe PDBsum

Gene Ontology
AmiGO / EGO

Search

PMC
articles

PubMed
articles

NCBI
proteins

In enzymology, a phosphoribokinase (EC 2.7.1.18) is an enzyme that catalyzes the chemical reaction

ATP + D-ribose 5-phosphate

{\displaystyle \rightleftharpoons }

ADP + D-ribose 1,5-bisphosphate

Thus, the two substrates of this enzyme are ATP and D-ribose 5-phosphate, whereas its two products are ADP and D-ribose 1,5-bisphosphate.
This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing groups (phosphotransferases) with an alcohol group as acceptor. The systematic name of this enzyme class is ATP:D-ribose-5-phosphate 1-phosphotransferase. This enzyme is also called phosphoribokinase (phosphorylating).
References[edit]

Krebs EG (1966). “Phosphorylase b kinase from rabbit muscle”. Methods Enzymol. Methods in Enzymology. 8: 543–546. doi:10.1016/0076-6879(66)08097-2. ISBN 978-0-12-181808-1. 
Scarano E (1953). “Quoted by H.M. Kalckar The role of phosphoglycosyl compounds in the biosynthesis of nucleosides and nucleotides”. Biochim. Biophys. Acta. 12 (1–2): 250–264. doi:10.1016/0006-3002(53)90144-9. PMID 13115434. 

v
t
e

Transferases: phosphorus-containing groups (EC 2.7)

2.7.1-2.7.4:
phosphotransferase/kinase
(PO4)

2.7.1: OH acceptor

Hexo-
Gluco-
Fructo-

Hepatic

Galacto-
Phosphofructo-

1
Liver
Muscle
Platelet
2

Riboflavin
Shikimate
Thymidine

ADP-thymidine

NAD+
Glycerol
Pantothenate
Mevalonate
Pyruvate
Deoxycytidine
PFP
Diacylglycerol
Phosphoinositide 3

Class I PI 3
Class II PI 3

Sphingosine
Glucose-1,6-bisphosphate synthase

2.7.2: COOH acceptor

Phosphoglycerate
Aspartate kinase

2.7.3: N acceptor

Creatine

2.7.4: PO4 acceptor

Phosphomevalonate
Adenylate
Nucleoside-diphosphate
Uridylate
Guanylate
Thiamine-diphosphate

2.7.6: diphosphotransferase
(P2O7)

Ribose-phosphate diphosphokinase
Thiamine diphosphokinase

2.7.7: nucleotidyltransferase
(PO4-nucleoside)

Polymerase

DNA polymerase

DNA-directed DNA polymerase
I
II
III
IV
V

RNA-directed DNA polymerase
Reverse transcriptase

Telomerase

DNA nuc
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